Welcome to my blog! My name is Amrita and I am a senior at BASIS Independent Silicon Valley. My project is titled The Effectiveness of Drug-Eluting Stents and will explore the most common complication with the insertion of heart stents in a clogged artery: in-stent restenosis. About 15 million people in the U.S. suffer from a buildup of plaque in their coronary artery. Patients often have a small, expandable tube, or stent, inserted in their artery to restore blood flow. The inevitable consequence of inserting a stent is injury to an artery’s vascular wall. Cells in contact with a stent initiate wound-healing or an inflammatory response. During this response, vascular smooth muscle and endothelial cells migrate and proliferate and re-block blood flow, defeating the purpose of stent insertion. My project will focus on this complication, also known as restenosis, and how it can be minimized through the use of drug-eluting stents. Drug-eluting stents elute anti-inflammatory drug compounds in order to minimize complications. I will be working with Dr. Michael S. Conte at the UCSF Heart and Vascular Center to determine the role of different drugs in cell proliferation. In addition, I will study the effect of more recent compounds that play a role in the post-intervention inflammatory response. I hope to not only create a comparative analysis of drugs currently used in stents and their efficacy in preventing complications, but also explore recent discoveries in heart stent research.